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The Aspirin Alternative Your Doctor Never Told You About
Thursday, March 8th 2018 at 1:45 pm
Sayer Ji, Founder
This article is copyrighted by GreenMedInfo LLC, 2019
Millions use aspirin daily without realizing its true dangers. The good news is that there is a natural alternative which preliminary research indicates is safer and more effective
WARNING: Never discontinue a pharmaceutical product without the guidance of a physician. Doing so could have serious, if not life threatening side effects. This article is for informational purposes only. Nothing here is intended as or should be substituted for medical advice.
Aspirin is taken faithfully by millions every day as a preventive measure against heart attack, often without the user having any awareness of the serious health risks associated with it, some potentially fatal. You can find over 60 adverse effects of aspirin if you have any doubts about how serious a concern this is.
Aspirin’s widespread popularity is based on its much-touted blood-thinning properties. But there are safer, surprisingly more effective and far more natural alternatives on the market today.
For instance, pycnogenol, a branded form of an extract of French maritime pine bark, can be found on the shelves of thousands of health food stores around the country, and unique among natural products, has a broad base of human clinical research supporting its use for a wide variety of health conditions. Moreover, in cross comparison tests, pycnogenol has been found at least as effective as aspirin in preventing blood from clotting, but at significantly lower doses and with a superior safety profile.
Smoker’s Study Proves Pycnogenol More Effective and Safer Than Aspirin
In a previous article titled, “The Powerful Aspirin Alternative That Grows on Trees,” we featured a 1999 clinical study published in Thrombotic Research that found that when habitual smokers were given either 500 mg of aspirin or anywhere between 100-200 mg of pycnogenol, the pycnogenol group experienced equivalent platelet aggregation inhibiting effects but with much lower bleeding times:
Thus, smoking-induced enhanced platelet aggregation was inhibited by 500 mg Aspirin as well as by a lower range of 100-125 mg Pycnogenol. Aspirin significantly (p<0.001) increased bleeding time from 167 to 236 seconds while Pycnogenol did not.These observations suggest an advantageous risk-benefit ratio for Pycnogenol.”
This is a highly significant finding, as aspirin-induced bleeding can result in significantly increased morbidity and mortality. One might ask, if pycnogenol is as effective a ‘blood thinner’ as aspirin but without the same side effects, then what is the downside of using the natural alternative?
Study Confirms Pycnogenol’s Superiority to Aspirin
Research comparing pycnogenol to aspirin as a blood thinner has been sparse, but a new study promises to add additional weight to the previously reported finding of pycnogenol’s superiority. Published this year in the Italian journal Panminerva Medica and titled, “Recurrence of retinal vein thrombosis with Pycnogenol® or Aspirin® supplementation: a registry study,” researchers compared the use of either pycnogenol or aspirin in the prevention of retinal vein thrombosis recurrence after a first episode.
Retinal vein thrombosis is considered to be a relatively common condition intimately related to other conditions that afflict the vascular system, such as hypertension, arteriosclerosis and diabetes.
The study methods were described as follows:
Possible management options – chosen by patients – were: standard management; standard management + oral Aspirin® 100 mg once/day (if there were no tolerability problems before admission); standard management + Pycnogenol® two 50 mg capsules per day (for a total of 100 mg/day). Number of subjects, age, sex, distribution, percentage of smokers, and vision were comparable.”
The results were reported as follows:
Recurrent RVT was seen in 17.39% of controls and in 3.56% of subjects supplemented with Pycnogenol® (P<0.05 vs. controls). There was RVT in 15.38% of the subjects using Aspirin®. The incidence of RVT was 4.88 times higher with standard management in comparison with the supplement group and 4.32 lower with Pycnogenol® supplementation in comparison with Aspirin®. Vision level was better with Pycnogenol® (20/25 at nine months; P<0.05). With Pycnogenol®, edema at the retinal level was also significantly reduced compared to the other groups. Pycnogenol® has a very good safety profile. In the Aspirin® group 26 completed 9 months and 6 subjects dropped out for tolerability problems. In the Aspirin® group, 2 minor, subclinical, retinal, hemorrhagic episodes during the follow-up were observed (2 subjects out of 26, equivalent to 7.69%). This pilot registry indicates that Pycnogenol® seems to reduce the recurrence of RVT without side effects. It does not induce new hemorrhagic episodes that may be theoretically linked to the use of Aspirin® (or other antiplatelets).”
As you can see, the clear winner in this comparison study was pycnogenol. Not only was the incidence of recurrent retinal vein thrombosis almost five times higher in the aspirin group, vision and retinal swelling (edema) was significantly lower in the pycnogenol group, as well. Moreover, whereas the pycnogenol group had no reported side effects, 6 of the 26 subjects in the aspirin group dropped out due to tolerability issues, and 7.69% of the aspirin group (2 subjects of 26) were found to have retinal bleeding as a side effect in the follow-up period.
Nature Provides Time-Tested Solutions
We really shouldn’t be surprised that a naturally occurring complex of phytocompounds (i.e. pycnogenol) should outperform a synthetic drug, considering that our bodies have co-evolved for millions of years with natural things, (e.g. foods, herbs, spices), and only a hundred or more with synthetic ones, (e.g. patent drugs). Pycnogenol, as a bark extract, is about 65-75 percent proanthocyanidins (procyanidins), a class of polyphenols found in a wide variety of plants, many of which have been in the human diet since the inception of our species and before. Some classical examples include green and black tea, cranberry, bilberry, cocoa beans, cinnamon, and black currant. Polyphenols, of course, are powerful antoxidants, as well as signaling molecules, which likely perform a variety of gene-regulatory functions, that may have value in a wide range of health conditions.
Suffice it to say that as the biomedical machine moves forward, and we see an increasingly voluminous body of literature investigating the health benefits and mechanisms of action underpinning natural interventions for disease prevention and treatment, we will become increasingly compelled to choose time-tested, natural alternatives to synthetic chemicals, as the former are not only much safer but often more effective than most scientists and physicians ever dreamed possible.
 Prisco D, Marcucci R. Retinal vein thrombosis: risk factors, pathogenesis and therapeutic approach. Pathophysiol Haemost Thromb. 2002 Sep-Dec;32(5-6):308-11. Review. PubMed PMID: 13679663
Sayer Ji is founder of Greenmedinfo.com, a reviewer at the International Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of the National Health Federation, Steering Committee Member of the Global Non-GMO Foundation.
The Powerful Aspirin Alternative Your Doctor Never Told You About
Friday, April 12th 2019 at 4:15 am
Sayer Ji, Founder
This article is copyrighted by GreenMedInfo LLC, 2019
Given the newly released cardiovascular disease prevention guidelines recommending against daily low-dose aspirin use, natural, safe and effective alternatives are needed now more than ever. Thankfully, one particularly therapeutic alternative has been known about by the biomedical research community for decades…
In a previous article titled “The Evidence Against Aspirin and For Natural Alternatives,” we discussed the clear and present danger linked with the use of aspirin as well as several clinically proven alternatives that feature significant side benefits as opposed to aspirin’s many known side effects.
Since writing this article, even more evidence has accumulated indicating that aspirin’s risks outweigh its benefits. Most notably, a 15-year Dutch study published in the journal Heart found that among 27,939 healthy female health professionals (average age 54) randomized to receive either 100 mg of aspirin every day or a placebo the risk of gastrointestinal bleeding outweighed the benefit of the intervention for colorectal cancer and cardiovascular disease prevention in those under 65 years of age. Most recently, last month, new cardiovascular disease prevention guidelines submitted jointly by the American College of Cardiology and the American Heart Associated and published in the Journal of the American College of Cardiology, earlier this year, contradict decades of routine medical advice by explicitly advising against the daily use of low-dose or baby aspirin (75-100 mg) as a preventive health strategy against stroke or heart attack, in most cases.
Of course, aspirin is not alone as far as dangerous side effects are concerned. The entire non-steroidal anti-inflammatory (NSAID) category of prescription and over-the-counter drugs is fraught with serious danger. Ibuprofen, for instance, is known to kill thousands each year, and is believed no less dangerous than Merck’s COX-2 inhibitor NSAID drug Vioxx which caused between 88,000-140,000 cases of serious heart disease in the five years it was on the market (1999-2004). Tylenol is so profoundly toxic to the liver that contributing writer Dr. Michael Murray recently asked in his Op-Ed piece, “Is it Time for the FDA to Remove Tylenol From the Market?” Just as serious are tylenol’s empathy destroying properties that were only identified four years ago.
Given the dire state of affairs associated with pharmaceutical intervention for chronic pain issues, what can folks do who don’t want to kill themselves along with their pain?
Pine Bark Extract (Pycnogenol) Puts Aspirin To Shame
When it comes to aspirin alternatives, one promising contender is pycnogenol, a powerful antioxidant extracted from French maritime pine bark, backed by over 40 years of research,
In 1999, a remarkable study published in the journal Thrombotic Research found that pycnogenol was superior (i.e. effective at a lower dosage) to aspirin at inhibiting smoking-induced clotting, without the significant (and potentially life-threatening) increase in bleeding time associated with aspirin use. The abstract is well worth reading in its entirety:
“The effects of a bioflavonoid mixture, Pycnogenol, were assessed on platelet function in humans. Cigarette smoking increased heart rate and blood pressure. These increases were not influenced by oral consumption of Pycnogenol or Aspirin just before smoking. However, increased platelet reactivity yielding aggregation 2 hours after smoking was prevented by 500 mg Aspirin or 100 mg Pycnogenol in 22 German heavy smokers. In a group of 16 American smokers, blood pressure increased after smoking. It was unchanged after intake of 500 mg Aspirin or 125 mg Pycnogenol. In another group of 19 American smokers, increased platelet aggregation was more significantly reduced by 200 than either 150 mg or 100 mg Pycnogenol supplementation. This study showed that a single, high dose, 200 mg Pycnogenol, remained effective for over 6 days against smoking-induced platelet aggregation. Smoking increased platelet aggregation that was prevented after administration of 500 mg Aspirin and 125 mg Pycnogenol. Thus, smoking-induced enhanced platelet aggregation was inhibited by 500 mg Aspirin as well as by a lower range of 100-125 mg Pycnogenol. Aspirin significantly (p<0.001) increased bleeding time from 167 to 236 seconds while Pycnogenol did not. These observations suggest an advantageous risk-benefit ratio for Pycnogenol.” [emphasis added]
As emphasized in bold above, pycnogenol unlike aspirin did not significantly increase bleeding time. This has profound implications, as aspirin’s potent anti-platelet/’blood thinning’ properties can also cause life-threatening hemorrhagic events. If this study is accurate and pycnogenol is more effective at decreasing pathologic platelet aggregation at a lower dose without causing the increased bleeding linked to aspirin, then it is clearly a superior natural alternative worthy of far more attention by the conventional medical establishment and research community than it presently receives.
Not Just A Drug Alternative
Pycnogenol, like so many other natural interventions, has a wide range of side benefits that may confer significant advantage when it comes to reducing cardiovascular disease risk. For instance, pycnogenol is also:
- Blood Pressure Reducing/Endothelial Function Enhancer: A number of clinical studies indicate that pycnogenol is therapeutic for those suffering with hypertension. Pycnogenol actually addresses a root cause of hypertension and cardiovascular disease in general, namely, endothelial dysfunction (the inability of the inner lining of the blood vessels to function correctly, e.g. fully dilate). It has been shown to prevent damage in microcirculation in hypertensive patients, as well as reducing the dose of blood pressure drugs in hypertensive patients, including hypertensive diabetic patients. It has even been found to reduce intraocular hypertension found in glaucoma patients.
- Anti-Inflammatory Effects: There is a growing appreciation among the medical community that inflammation contributes to cardiovascular disease. Several markers, including C-reactive protein are now being fore grounded as being at least as important in determining cardiovascular disease risk as various blood lipids and/or their ratios, such as low-density lipoprotein (LDL). Pycnogenol has been found to reduce C-reactive protein in hypertensive patients. Pycnogenol has been found to rapidly modulate downward (inhibit) both Cox-1 and Cox-2 enzyme activity in human subjects, resulting in reduced expression of these inflammation-promoting enzymes within 30 minutes post-ingestion. Another observed anti-inflammatory effect of pycnogenol is its ability to down-regulate the class of inflammatory enzymes known as matrix metalloproteinases (MMPs). Pycnogenol has also been found to significantly inhibit NF-kappaB activation, a key body-wide regulator of inflammation levels whose overexpression and/or dysregulation may result in pathologic cardiovascular manifestations. Finally, pycnogenol has been found to reduce fibrinogen levels, a glycoprotein that contributes to the formation of blood clots; fibrinogen has been identified as an independent risk factor for cardiovascular disease.
- The Ideal Air Travel Companion: In a previous article entitled, “How Pine Bark Extract Could Save Air Travelers Lives,” we delve into a compelling body of research that indicates pycnogenol may be the perfect preventive remedy for preventing flight-associated thrombosis, edema, and concerns related to radiotoxicity and immune suppression.
Given the evidence for pycnogenol’s pleotrophic cardioprotective properties, we hope that pycnogenol will become more commonly recommended by health care practitioners as the medical paradigm continues to evolve past its reliance on synthetic chemicals, eventually (we hope) returning to natural, increasingly evidence-based interventions. However, it is important that we don’t fall prey to the one-disease-one-pill model, convincing ourselves to focus on popping pills – this time natural ones – as simply countermeasures or ‘insurance’ against the well-known harms associated with the standard American diet, lack of exercise and uncontrolled stress. The ultimate goal is to remove the need for pills altogether, focusing on preventing cardiovascular disease from the ground up and inside out, e.g. letting high quality food, clean water and air, and a healthy attitude nourish and sustain your health and well-being.
 Ximing Liu, Junping Wei, Fengsen Tan, Shengming Zhou, Gudrun Würthwein, Peter Rohdewald. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci. 2004 Jan 2;74(7):855-62. PMID: 14659974
 Gianni Belcaro, Maria Rosaria Cesarone, Andrea Ricci, Umberto Cornelli, Peter Rodhewald, Andrea Ledda, Andrea Di Renzo, Stefano Stuard, Marisa Cacchio, Giulia Vinciguerra, Giuseppe Gizzi, Luciano Pellegrini, Mark Dugall, Filiberto Fano. Control of edema in hypertensive subjects treated with calcium antagonist (nifedipine) or angiotensin-converting enzyme inhibitors with Pycnogenol. Clin Appl Thromb Hemost. 2006 Oct;12(4):440-4. PMID: 17000888
 Sherma Zibadi, Peter J Rohdewald, Danna Park, Ronald Ross Watson. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Nutr Res. 2008 May;28(5):315-20. PMID: 19083426
 Robert D Steigerwalt, Belcaro Gianni, Morazzoni Paolo, Ezio Bombardelli, Carolina Burki, Frank Schönlau. Effects of Mirtogenol on ocular blood flow and intraocular hypertension in asymptomatic subjects. Mol Vis. 2008;14:1288-92. Epub 2008 Jul 10. PMID: 18618008
 Maria Rosaria Cesarone, Gianni Belcaro, Stefano Stuard, Frank Schönlau, Andrea Di Renzo, Maria Giovanna Grossi, Mark Dugall, Umberto Cornelli, Marisa Cacchio, Giuseppe Gizzi, Luciano Pellegrini. Kidney flow and function in hypertension: protective effects of pycnogenol in hypertensive participants–a controlled study. J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):41-6. Epub 2010 Jan 22. PMID: 20097689
 Angelika Schäfer, Zuzana Chovanová, Jana Muchová, Katarína Sumegová, Anna Liptáková, Zdenka Duracková, Petra Högger. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol). Biomed Pharmacother. 2006 Jan;60(1):5-9. Epub 2005 Oct 26. PMID: 16330178
 Tanja Grimm, Angelika Schäfer, Petra Högger. Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol). Wei Sheng Yan Jiu. 2011 Jan;40(1):103-6. PMID: 14990359
 Tanja Grimm, Zuzana Chovanová, Jana Muchová, Katarína Sumegová, Anna Liptáková, Zdenka Duracková, Petra Högger. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). J Inflamm (Lond). 2006;3:1. Epub 2006 Jan 27. PMID: 16441890
 G Belcaro, M R Cesarone, S Errichi, C Zulli, B M Errichi, G Vinciguerra, A Ledda, A Di Renzo, S Stuard, M Dugall, L Pellegrini, G Gizzi, E Ippolito, A Ricci, M Cacchio, G Cipollone, I Ruffini, F Fano, M Hosoi, P Rohdewald. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol. Redox Rep. 2008;13(6):271-6. PMID: 19017467
Originally published: 2017-07-23
Article updated: 2019-04-11
Sayer Ji is founder of Greenmedinfo.com, a reviewer at the International Journal of Human Nutrition and Functional Medicine, Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of the National Health Federation, Steering Committee Member of the Global Non-GMO Foundation.
There are so many natural substances that can be used instead of aspirin or other drugs:
30 Substances Researched for Clotting:
|Prickly Pear Cactus|
|Olive leaf extract|
|Resveratrol: Cis- Form|
68 Substances Researched for Thrombosis
|Omega-3 Fatty Acids|
|Vitamin E: Gamma-tocotrienol|
|Grape Seed Extract|
|Pine Bark Extract|
|Pycnogenol (Pine Bark)|
|Fermented Foods and Beverages|
|Lion’s Mane (Hericium Erinaceus)|
|Olive leaf extract|
|Red Wine Extract|
|Resveratrol: Cis- Form|
13 Problem Substances Researched for Thrombosis ie they make the problem worse. There are lots of natural substances above that you can use instead of these.
|Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)|
|Ethinyl Estradiol plus Lynestrenol|